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Run LLM Locally

Qwen2.5 72B Instruct on the H100 PCIe

With 80 GB of VRAM, the H100 PCIe runs Qwen2.5 72B Instruct at Q4_K_M entirely on the GPU with an 8K context (about 46.6 GB needed). At Q8_0 it does not fit in VRAM.

Qwen2.5 72B Instruct

Q4_K_M · 8K context

Excellent

The model needs about 46.6 GB and fits in the 77.6 GB available, with 31 GB to spare.

Your hardware
H100 PCIe 80 GB · 64 GB RAM
Estimated memory
~46.6 GB estimate
VRAM (usable memory)
77.6 GB
GPU only
Yes
CPU/GPU offload
Not required
Generation speed
29–41 tok/s estimate
Largest context in fast memory
102K tokens
Confidence: low

Based on: memory bandwidth (2,000 GB/s) and model size

Memory breakdown

~46.6 GB (45.3 GB–47.9 GB) needed · estimate

Fits entirely in VRAM · 31 GB left

  • Model weights41 GB
  • KV cache2.5 GB
  • Runtime overhead0.9 GB
  • Safety margin2.2 GB
Assumptions: context 8K tokens · KV cache f16 · llama.cpp (CUDA) · flash attention on · weights = real file size

EstimateData updated 24 days agoSource: Run LLM Locally engine, Hugging Face config.json + model card

What makes this estimate less reliable

  • no benchmark for this hardware and model yet

Other quantizations on the H100 PCIe

Qwen2.5 72B Instruct on H100 PCIe + 64 GB RAM · 8K context
Qwen2.5 72B Instruct Q8_08K~79.3 GB · 6.5–12 tok/s estimateCPU/GPU offload
Qwen2.5 72B Instruct Q6_K8K~62.1 GB · 23–31 tok/s estimateExcellent
Qwen2.5 72B Instruct Q5_K_M8K~54.1 GB · 26–35 tok/s estimateExcellent
Qwen2.5 72B Instruct Q4_K_M8K~46.6 GB · 29–41 tok/s estimateExcellent
Qwen2.5 72B Instruct IQ4_XS8K~42.4 GB · 32–45 tok/s estimateExcellent
Qwen2.5 72B Instruct Q3_K_M8K~38.2 GB · 35–49 tok/s estimateExcellent

Alternatives

Hardware that runs Qwen2.5 72B Instruct Q4_K_M entirely in memory

Prices and links follow the market you choose.

Radeon PRO W7900

AMD

CompatibleRuns Qwen2.5 72B Instruct Q4_K_M entirely in memory

Price not available

Availability unknown

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AMD Ryzen AI Max+ 395

Unified memory PC

CompatibleRuns Qwen2.5 72B Instruct Q4_K_M entirely in memory

Price not available

Availability unknown

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GeForce RTX 5090

Lowest memory tier

ExcellentRuns Qwen2.5 72B Instruct Q4_K_M entirely in memory

Price not available

Availability unknown

View on amazon.com

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No current offer imported for this market: the link opens a marketplace search.

Frequently asked questions

Can the H100 PCIe run Qwen2.5 72B Instruct?
The model needs about 46.6 GB and fits in the 77.6 GB available, with 31 GB to spare.
Which quantization should I use on the H100 PCIe?
Q6_K is the highest-precision quantization that fits entirely in VRAM at 8K context. ~62.1 GB / 77.6 GB.
What is the largest context on the H100 PCIe?
At Q4_K_M, about 102K tokens fit entirely in VRAM with an f16 KV cache. A q8_0 KV cache roughly doubles that.
How fast is Qwen2.5 72B Instruct (H100 PCIe)?
We estimate 29–41 tok/s (estimate, confidence low). Based on: memory bandwidth (2,000 GB/s) and model size.