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Run LLM Locally

Mistral Nemo 12B Instruct on the RTX 5080

With 16 GB of VRAM, the RTX 5080 runs Mistral Nemo 12B Instruct at Q4_K_M entirely on the GPU with an 8K context (about 9.4 GB needed). At Q8_0 it fits entirely.

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Mistral Nemo 12B Instruct

Q4_K_M · 8K context

Excellent

The model needs about 9.4 GB and fits in the 15.5 GB available, with 6.1 GB to spare.

Your hardware
RTX 5080 16 GB · 64 GB RAM
Estimated memory
~9.4 GB estimate
VRAM (usable memory)
15.5 GB
GPU only
Yes
CPU/GPU offload
Not required
Generation speed
75–106 tok/s estimate
Largest context in fast memory
45K tokens
Confidence: low

Based on: memory bandwidth (960 GB/s) and model size

Memory breakdown

~9.4 GB (9 GB–10 GB) needed · estimate

Fits entirely in VRAM · 6.1 GB left

  • Model weights7 GB
  • KV cache1.3 GB
  • Runtime overhead0.8 GB
  • Safety margin0.4 GB
Assumptions: context 8K tokens · KV cache f16 · llama.cpp (CUDA) · flash attention on · weights = real file size

EstimateData updated 24 days agoSource: Run LLM Locally engine, Hugging Face config.json + model card

What makes this estimate less reliable

  • no benchmark for this hardware and model yet

Other quantizations on the RTX 5080

Mistral Nemo 12B Instruct on RTX 5080 + 64 GB RAM · 8K context
Mistral Nemo 12B Instruct Q8_08K~14.9 GB · 48–66 tok/s estimateCompatible
Mistral Nemo 12B Instruct Q6_K8K~12 GB · 59–83 tok/s estimateExcellent
Mistral Nemo 12B Instruct Q5_K_M8K~10.7 GB · 66–93 tok/s estimateExcellent
Mistral Nemo 12B Instruct Q4_K_M8K~9.4 GB · 75–106 tok/s estimateExcellent
Mistral Nemo 12B Instruct IQ4_XS8K~8.7 GB · 81–116 tok/s estimateExcellent
Mistral Nemo 12B Instruct Q3_K_M8K~8.1 GB · 87–126 tok/s estimateExcellent

Alternatives

GPUs that run Mistral Nemo 12B Instruct Q4_K_M entirely in VRAM

Other models that fit the RTX 5080

Where to buy a RTX 5080

Prices and links follow the market you choose.

GeForce RTX 5080

16 GB GDDR7 · 960 GB/s · 360 W

ExcellentRuns Mistral Nemo 12B Instruct Q4_K_M entirely in memory

Price not available

Availability unknown

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Frequently asked questions

Can the RTX 5080 run Mistral Nemo 12B Instruct?
The model needs about 9.4 GB and fits in the 15.5 GB available, with 6.1 GB to spare.
Which quantization should I use on the RTX 5080?
Q8_0 is the highest-precision quantization that fits entirely in VRAM at 8K context. ~14.9 GB / 15.5 GB.
What is the largest context on the RTX 5080?
At Q4_K_M, about 45K tokens fit entirely in VRAM with an f16 KV cache. A q8_0 KV cache roughly doubles that.
How fast is Mistral Nemo 12B Instruct (RTX 5080)?
We estimate 75–106 tok/s (estimate, confidence low). Based on: memory bandwidth (960 GB/s) and model size.